|Biography:||I started my research experience in the field of ubiquitin proteasome system and proteomics in the Wellcome Trust Centre for Human Genetics, Oxford University, UK.|
Having completed my Master's in Biology, I worked at Oxford University as a research assistant in mass spectrometry and protein biochemistry (2005-2009)
I completed my Ph.D. in Clinical Medicine at Oxford University (2006-2010), with my research interests being focused on protein deubiquitination, protein mass spectrometry and host-pathogen interactions.
I am now a research assistant professor at the Institute for Genomics, Biocomputing and Biotechnology (IGBB). My research relates to mass spectrometry-based proteomics, molecular aspects of the host-pathogen interactions during bacterial infection as well as nanotoxicology.
|Research Interest: ||- protein turnover and ubiquitin proteasome system|
- protein post-translational modifications (ubiquitination, phosphorylation, acetylation, methylation etc.) and their impact on protein function
- host-pathogen interactions (type three secretion bacteria: Salmonella, Shigella, Yersinia)
- nanoparticles and toxicology
|Publications: ||Meisenberg, C., Tait, P., Dianova, I. I., Wright, K., Edelmann, M. J., Ternette, N., Tasaki, T., Kessler, B. M., Persons, J. L., Kwon, Y. T., & Dianov, G. L. (2012). Ubiquitin Ligase UBR3 Regulates Cellular Levels of the Essential DNA Repair Protein APE1 and Is Required for Genome Stability. Nucleic Acids Res. 40(2), 701-711. DOI:10.1093/nar/gkr744. [Document Site]|
Ross, M. K., & Edelmann, M. J. (2012). Carboxylesterases: A Multifunctional Enzyme Involved in Pesticide and Lipid Metabolism. Parameters for Pesticide QSAR and PBPK/PD models for Human Risk Assessment. ACS Books. 1099. DOI:10.1021/bk-2012-1099.ch010. [Document Site]
Edelmann, M. J., Kramer, H. B., & Kessler, B. M. (2010). Post-translational Modification of the Deubiquitinating Enzyme Otubain 1 Modulates Active RhoA Levels and Susceptibility to Yersinia Invasion. FEBS Journal. 277(11), 2515 – 2530. [Document Site]
Mortensen, M., Ferguson, D. J., Edelmann, M. J., Kessler, B., Morten, K. J., Komatsu, M., & Simon, A. K. (2010). Loss of Autophagy in Erythroid Cells Leads to Defective Removal of Mitochondria and Severe Anemia in Vivo. PNAS. 107(2), 832-7. [Document Site]
Edelmann, M. J., Iphöfer, A., Akutsu, M., Altun, M., DiGleria, K., Kramer, H. B., Fiebiger, E., Dhe-Paganon, S., & Kessler, B. M. (2009). Structural Basis and Specificity of Human Otubain 1-mediated Deubiquitination. Biochemistry Journal. 418(2), 379-90. [Document Site]
|Total Publications by this Author: 37|