HPC MSU
Name:Mariola J Edelmann
Associated Centers:Institute for Genomics, Biocomputing and Biotechnology
Position:Faculty
Email: MEdelmann@mafes.msstate.edu
Office:Wise Center/College of Veterinary Medicine, 1505
Office Phone:(662) 325-4217
Address:240 Wise Center
Mississippi State
MS 39762

Biography:I started my research experience in the field of ubiquitin proteasome system and proteomics in the Wellcome Trust Centre for Human Genetics, Oxford University, UK. I worked at Oxford University as a research assistant in mass spectrometry and protein biochemistry for over four years.

I also completed my Ph.D. in Clinical Medicine at Oxford University, with my research interests being focused on protein deubiquitination, protein mass spectrometry and host-pathogen interactions.

I worked as a research assistant professor at the Institute for Genomics, Biocomputing and Biotechnology (IGBB) in years 2010-2013, and at the moment I am an assistant professor at the Basic Science Department at the College of Veterinary Medicine, MSU.

My NIH-funded research primarily relates to the molecular aspects of the host-pathogen interactions during bacterial infections (Yersinia, Shigella, Salmonella). I am also interested in mass spectrometry-based proteomics, for instance finding new methods to quantify post-translational modifications and utilizing chemical biology methods to quantify and annotate enzymes.

Research Interest: - protein turnover and ubiquitin proteasome system
- host-pathogen interactions (type three secretion bacteria: Salmonella, Shigella, Yersinia)
- protein post-translational modifications (ubiquitination, phosphorylation, acetylation, methylation etc.) and their impact on protein function
- proteomics



Publications: Kummari, E., Alugubelly, N., Hsu, C., Dong, B., Nanduri, B., & Edelmann, M. J. (2015). Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation. PLOS ONE. PLOS. 1, 1-10. DOI:10.1371/journal.pone.0135531. [Document Site]

Edelmann, M. J., Shack, L. B., Naske, C. D., Walters, K. B., & Nanduri, B. (2014). SILAC-Based Quantitative Proteomic Analysis of Human Lung Cell Response to Copper Oxide Nanoparticles. PLOS ONE. 9(12), e114390. DOI:10.1371/journal.pone.0114390. [Document Site]

Edelmann, M. J., Kramer, H. B., & Kessler, B. M. (2010). Post-translational Modification of the Deubiquitinating Enzyme Otubain 1 Modulates Active RhoA Levels and Susceptibility to Yersinia Invasion. FEBS Journal. 277(11), 2515 2530. [Document Site]

Mortensen, M., Ferguson, D. J., Edelmann, M. J., Kessler, B., Morten, K. J., Komatsu, M., & Simon, A. K. (2010). Loss of Autophagy in Erythroid Cells Leads to Defective Removal of Mitochondria and Severe Anemia in Vivo. PNAS. 107(2), 832-7. [Document Site]

Edelmann, M. J., Iphöfer, A., Akutsu, M., Altun, M., DiGleria, K., Kramer, H. B., Fiebiger, E., Dhe-Paganon, S., & Kessler, B. M. (2009). Structural Basis and Specificity of Human Otubain 1-mediated Deubiquitination. Biochemistry Journal. 418(2), 379-90. [Document Site]

Total Publications by this Author: 46